Reduced levels of potential circulating biomarkers of cardiovascular diseases in apparently healthy vegetarianmen.

Navarro JA1, de Gouveia LA1, Rocha-Penha L2, Cinegaglia N2, Belo V3, Castro MM3, Sandrim VC4.

Abstract

BACKGROUND:

Several evidences report that a vegetarian diet is protector against cardiovascular diseases. Few studies have demonstrated the circulating profile of cardiovascular biomarkers in vegetarians. Therefore, the aims of the current study were compared the plasma concentrations of myeloperoxidase (MPO), metalloproteinase (MMP)-9, MMP-2, tissue inhibitor of MMP (TIMP)-1 and TIMP-2 between healthy vegetarian (Veg) and healthy omnivorous (Omn).

METHODS:

Using ELISA and multiplexed bead immunoassay, we measured in plasma from 43 Veg and 41 Omn the cardiovascular biomarkers concentrations cited above.

RESULTS:

We found significant lower concentrations of MPO, MMP-9, MMP-2 and MMP-9/TIMP-1 ratio in Veg compared to Omn (all P<0.05). Moreover, MMP-9 concentrations were correlated positively with leukocytes and neutrophils count in both groups (all P<0.05).

CONCLUSION:

A vegetarian diet is associated with a healthier profile of cardiovascular biomarkers compared to omnivorous.

KEYWORDS:

Cardiovascular biomarkers; MMP-2; MMP-9; MPO; Omnivorous; TIMP; Vegetarians

PMID:

 

27496081

 

DOI:

 

10.1016/j.cca.2016.08.002                                                                                                                                     

Clin Chim Acta. 2016 Oct 1;461:110-3. doi: 10.1016/j.cca.2016.08.002. Epub 2016 Aug 2